Tissue Sealants and Tissue Adhesive Market Size, Share, Growth & Trends 2034

Tissue Sealants and Tissue Adhesive Market: Industry Prospective

The global tissue sealants and tissue adhesive market size was worth around USD 1901.93 Million in 2024 and is predicted to grow to around USD 4340.04 Million by 2034 with a compound annual growth rate (CAGR) of roughly 8.6% between 2025 and 2034. The report analyzes the global tissue sealants and tissue adhesive market's drivers, restraints/challenges, and the effect they have on the demands during the projection period. In addition, the report explores emerging opportunities in the tissue sealants and tissue adhesive industry.

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Tissue Sealants and Tissue Adhesive Market: Overview

Sealants are materials used by surgeons to heal tissue that has been injured by surgery or injury. Skin, internal organs, and blood vessels are among the tissues that have been damaged. Sealants are used in combination with mechanical procedures like sutures and staples to assist minimize blood loss and avoiding leaks. Tissue adhesives are liquid monomers that, when exposed to a moist surface (skin), begin an exothermic reaction, transforming into a polymer that establishes a strong tissue connection.

Secure skin closure is very basic and essential step in every surgical procedure. If the skin closure devices fail to provide the required strength and support to the skin tissue, there is a possibility that the wound edges can get separated, or it can offer a potential way for bacterial contamination. A promising alternative to the traditional closure techniques is tissue sealants and tissue adhesives. They form physically powerful bond crossways apposed wound boundaries and allow normal healing to occur below. Tissue sealants and adhesives save time in wound repair, provide a flexible water-resistant defensive coating and eradicate the need for suture removal. Some tissue glue examples are Cyanoacrylate, octyl cyanoacrylate (Dermabond), enbucrilate (Histoacryl), and N-butyl cyanoacrylate (Indermil, Liquiband). 

Key Insights

• As per the analysis shared by our research analyst, the global tissue sealants and tissue adhesive market is estimated to grow annually at a CAGR of around 8.6% over the forecast period (2025-2034).
• Regarding revenue, the global tissue sealants and tissue adhesive market size was valued at around USD 1901.93 Million in 2024 and is projected to reach USD 4340.04 Million by 2034.
• The tissue sealants and tissue adhesive market is projected to grow at a significant rate due to increasing surgical procedures and wound closure advancements.
• Based on Product, the Natural or Biological Sealants & Adhesives segment is expected to lead the global market.
• On the basis of Application, the General Surgery segment is growing at a high rate and will continue to dominate the global market.
• Based on the End-user, the Ambulatory Surgery Centers segment is projected to swipe the largest market share.
• Based on region, North America is predicted to dominate the global market during the forecast period.

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Tissue Sealants and Tissue Adhesive Market: Growth Drivers

Increase in the number of orthopedic and cardiovascular procedures to foster the market

Over the forecast period, rising cardiovascular and orthopedic surgeries are expected to drive revenue growth in the global tissue sealants and tissue adhesive market. The ease of availability of novel tissue adhesives and tissue sealants among end users, combined with rising disposable money, is a major driver in the global increase in such procedures. Adhesives are essential in general surgery. Natural and manufactured polymeric materials can be used to create three-dimensional networks that adhere to target tissues chemically and physically, acting as adhesives, sealants, or hemostats. Because adhesives and sealants are such an important aspect of general surgery, demand for them will rise as the number of procedures performed increases. As a result, market growth is likely to be boosted.

Tissue Sealants and Tissue Adhesive Market: Restraints

Less market penetration for tissue sealants and adhesives in developing countries to hinder the growth

The market's growth is also likely to be hampered by the dearth of acceptance of tissue glue and bio-adhesive sealants in developing markets. This is due to a lack of knowledge about the advantages, cost-effectiveness, therapeutic application, and reliability of tissue adhesive and tissue sealants against alternative procedures or products, as well as tissue healing therapies.

Tissue Sealants and Tissue Adhesive Market: Opportunities

Technological advancement for product launches to create numerous opportunities for market growth

Companies have been working on the development of novel tissue glue and bio-adhesive sealants to reach a variety of consumers, including toddlers, and young and elderly patients, during the last few years. Tissue sealants are currently used to protect sensitive, fragile, skin from damage, and to prevent cross-contamination & infection transmission. For innovative product launches, major companies are investing heavily in R&D activities. All such factors are likely to generate numerous opportunities for the global tissue sealants and tissue adhesive market growth during the forecast period.

Tissue Sealants and Tissue Adhesive Market: Challenges

Limitations in the development of tissue adhesive act as a major challenge to market growth.

Despite the fact that many tissue adhesives form strong connections with tissue, they are frequently not designed for specific tissue applications. Tissue adhesives, in particular, do not biodegrade at a rate consistent with tissue repair, cause an unwanted inflammatory response upon adhesion or disintegration, fail to cohere in high-load-bearing applications, or do not match the characteristics of the underlying tissue. In the early stages of development, rigorous differentiation of target applications and a greater in-depth investigation of tissue-surface features and tissue-environmental parameters are necessary.

Despite the fact that the surface of the tissue and the surrounding environment change amongst tissues, the most typical technique is to utilize one type of adhesive for all conceivable tissues. This "one-size-fits-all" approach frequently results in tissue adhesive misuse, leading to inferior performance and dampening enthusiasm for potentially promising new materials. This could also lead to an incorrect cost-effectiveness analysis for specified unmet clinical requirements in the early stages of development, culminating in an exaggeration of cost in later stages of development and obstructing clinical translation. A failure to understand the physiological effects of adhesive materials after implantation is another factor for the research-to-product mismatch. All such limitations may pose challenges to market growth.

Tissue Sealants and Tissue Adhesive Market: Segmentation

The global tissue sealants and tissue adhesive market is categorized based on product, application, end-user, and region.

Based on the product, the market is divided into semi-synthetic & synthetic adhesives and biological or natural sealants.

The application segment consists of neurosurgery, cosmetic surgery, cardiovascular surgery, gynecology surgery, orthopedic surgery, general surgery, and other applications.

The end-user segment is bifurcated into ambulatory surgery centers, specialty clinics, and hospitals.

Tissue Sealants and Tissue Adhesive Market: Report Scope    

Recent Developments

• In January 2020, Polyganics, a medical technology business that develops, manufactures, and sells bioresorbable medical devices, revealed that LIQOSEAL®, its effortless and unique dural sealant patch, has received CE certification and will be available in Europe immediately.
• In December 2019, Johnson & Johnson Medical Devices Companies announced that Ethicon has released VISTASEAL Fibrin Sealant (Human) to assist surgeons to minimize bleeding during surgery. VISTASEAL Fibrin Sealant (Human) is made up of fibrinogen and thrombin, which are both clotting proteins present in human plasma. It creates a fast, adherent, and permanent clot after being placed on the bleeding site and has been shown to maintain hemostasis (blood stoppage) in high-risk patients.

Tissue Sealants and Tissue Adhesive Market: Regional Landscape

North America to be the leader in the global market

Among the regions, North America is estimated to lead the global tissue sealants and tissue adhesive market during the forecast period. Because of its large population and technical advancements, North America accounted for the largest share of tissue sealants and tissue adhesive. However, the market for tissue sealants and tissue adhesives is expected to expand significantly in Asia Pacific countries. Factors such as state-of-the-art medical research facilities and rising investments in healthcare infrastructure in this region, and also heightened understanding among both physicians & patients relating therapeutic approaches, enhanced life expectancy, and a rising population will push growing demands for tissue sealants and tissue adhesives in the Asia Pacific region.

Tissue Sealants and Tissue Adhesive Market: Competitive Landscape

The report provides a company market share analysis to give a broader overview of the key market players. In addition, the report also covers key strategic developments of the market, including acquisitions & mergers, new product launches, agreements, partnerships, collaborations & joint ventures, research & development, and regional expansion of major participants involved in the tissue sealants and tissue adhesive market on a global and regional basis.

• Integra LifeSciences
• C.R Bard
• Smith & Nephew
• Exapharma
• Johnson & Johnson
• Baxter International Inc.
• Tissuemed Ltd.
• Chemence Medical, Inc.
• Cohera Medical, Inc.
• Luna Innovations Incorporated

The global tissue sealants and tissue adhesive market is segmented as follows:

By Product

• Natural or Biological Sealants and Adhesives
• Synthetic and Semi-Synthetic Adhesives

By Application

• General Surgery
• Orthopedic Surgery
• Gynecology Surgery
• Cardiovascular Surgery
• Cosmetic Surgery
• Neurosurgery
• Other Applications

By End-user

• Hospitals
• Specialty Clinics
• Ambulatory Surgery Centers

By Region

• North America
  • The U.S.
  • Canada
  • Mexico
• Europe
  • France
  • The UK
  • Spain
  • Germany
  • Italy
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • Australia
  • South Korea
  • Rest of Asia Pacific
• The Middle East & Africa
  • Saudi Arabia
  • UAE
  • Egypt
  • Kuwait
  • South Africa
  • Rest of the Middle East & Africa
• Latin America
  • Brazil
  • Argentina
  • Rest of Latin America