Protein Purification & Isolation Market Trend, Share, Growth, Size, Techniques, Forecast 2030

Protein Purification & Isolation Market: Industry Perspective

The global protein purification & isolation market size was worth USD 7.5 billion in 2021 and is estimated to grow to USD 13.35 billion by 2028, with a compound annual growth rate (CAGR) of about 10.1% over the forecast period. The report analyzes the protein purification & isolation market's drivers, restraints/challenges, and the effect they have on the demands during the projection period. In addition, the report explores emerging opportunities in the protein purification & isolation market.

Protein Purification & Isolation Market: Overview

Protein purification & isolation refer to a set of processes for isolating a type of protein from a complex mixture of tissues, cells, or organisms. The expanding relevance of generating novel ligands, including such protein-based pharmaceutical compounds, is one of the key drivers driving demand for protein purifying & isolation. Additionally, the market is expected to expand due to increased demand for purification kits in quick screen testing. Furthermore, protein purification & isolation sales are increasing due to a move toward technologically complex protein purification instruments and the development of the proteomic market. All of these factors, as well as increased R&D in the biopharmaceutical industry, are expected to raise the global protein purification & isolation market share throughout the forecast period. Protein purifying & isolation sales are expected to rise as untapped growth opportunities, and protein therapies benefit the sector. Furthermore, the growing usage of automated analyzers is expected to increase the demand for protein purifying & isolation equipment. Due to ongoing technological advancements, protein purification & separation products are in high demand. Recent developments in the protein purifying & separation industry include the increasing popularity of agar beads, alternative polymers, magnetic & protein beads, and ligand tagging methods. However, low instrument acceptance rates, the difficulties of maintaining purification kits that fulfill all proposals, and high tool costs limit the market growth.

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COVID-19 Impact:

The unanticipated COVID-19 outbreak triggered the global deployment of lockdown measures, resulting in delays in protein purifying & isolating import and export. The pandemic also reduced the amount of money available from individual investors and governments worldwide.

Key Insights

• The global protein purification & isolation market value is predicted to grow at a CAGR of 10.1% over the forecast period.
• The global protein purification & isolation market was worth USD 7.5 billion in 2021 and is estimated to grow to USD 13.35 billion by 2028.
• Increased investment in pharmaceutical and biotechnological R&D, growing demand for more accurate and rapid purification kits, and technical improvements are key factors driving the market growth.
• The protein purification & isolation market is hampered by poor instrument acceptance rates, the challenges of maintaining purifying kits that meet all demands, and high tool costs.
• By technology, the chromatography segment had the highest market share of 29.1% in 2021.
• By end-user, the CROs category is likely to expand significantly throughout the forecast period, owing to an increase in the number of clinical studies outsourced by drug research organizations, and high R&D spending.
• North America had the largest revenue share in 2021, accounting for more than 45% of total revenue.

Protein Purification & Isolation Market: Growth Drivers

Rising affinity chromatography adoption is propelling the global market growth

According to the National Center for Biotechnology Information (NCBI), affinities chromatography was used in more than 60% of all purification techniques in 2020. It relies on a molecule bonded to a column to recognize the target molecule. The target protein is isolated using affinity chromatography by its particular binding characteristics to an immobilized ligand. Furthermore, affinity chromatography is based on a protein's selective and reversible binding to a matrix-bound ligand. Affinity chromatography, proteomics, immunoprecipitation, and enzymatic assay are a few frequently used techniques for protein purification & isolation.

Protein Purification & Isolation Market: Restraints

Lower acceptance rates for instruments and difficulty in maintaining one size fits all purifying kits may hamper the global market growth

Several affinity tags can be employed for protein purification & isolation. In terms of size, binding power, and impact on protein stability and solubility, affinity tags come in a wide range of sizes. In addition, affinity purifying tags are frequently linked to a target recombinant protein as native protein purification & isolation can be challenging, allowing the tag to be utilized to identify or detect the target protein. Thus, instruments that result in a lower adoption rate and the difficulties of sustaining purification kits that match all proposals operate as roadblocks to global protein purification & isolation market growth.

Protein Purification & Isolation Market: Opportunities

Continuous technological advancements in protein purification & isolation products bring up several growth opportunities

One of the important developments in the protein purifying & isolation market is the advancement of single-use technologies as well as automated purification equipment. Protein purification & isolation technologies are widely utilized in applications such as drug screening, ion-exchange chromatography, gel electrophoresis, biomarkers discovery, protein therapies, and target identification. Comparing it to alternatives, chromatography is among the most precise and sensitive technologies for protein purifying & isolation. Various companies are thus concentrating on commercializing new products relying on this technology to extend their product line. Ongoing technical breakthroughs develop new growth prospects for protein purifying & isolation solutions in the industry.

Protein Purification & Isolation Market: Challenges

The high price of protein isolation and purification kits continues to be a global challenge

The increasing demand for advanced instruments and test kits that provide fast, reliable, and reproducible protein purification at a low cost is driving up the price of these kits and making it difficult for new companies to enter the market, which is one of the major factors limiting the global protein purification & isolation market growth. For instance, protein purification & isolation kits vary from USD 450 to USD 2000. However, the high cost of protein purifying & isolation equipment and the scarcity of qualified workers are factors challenging industry expansion.

Protein Purification & Isolation Market: Segmentation

The global protein purification & isolation market is segregated on the product, technology, application, end-use, and region.

By product, the market is divided into instruments and consumables. Among these, the consumables segment dominates the market, accounting for more than 60% of global sales. Based on technology outlook, the market is classified into ultrafiltration, precipitation, chromatography, electrophoresis, western blotting, and others. The chromatography segment held 29.1% of the market share in 2021 due to the growing focus of several companies on commercializing new goods based on this technology to diversify their product lines. Over the forecast period, the chromatography market is expected to develop at the fastest rate.

By application, the market is classified into drug screening, biomarker discovery, protein-protein interaction studies, and diagnostics. The protein-protein interaction studies segment dominates the market, accounting for more than 30% of worldwide revenue share in 2021. Based on end-use, the market is classified into academic & research institutes, hospitals, pharmaceutical & biotechnological companies, and CROs. The CROs segment is expected to grow significantly throughout the projected period, owing to an increasing number of preclinical studies outsourced by drug research companies and large R&D spending.

Recent Developments

• October 2021 - Purolite, a resin-based chromatography separation company, introduced two next-generation chromatographic resins. The first protein is Praesto Jetted A50 HipH. It is a 50m homogeneous agarose bead-based alkaline stable resin. It is intended to deal with the purification of antibodies or even other pH-sensitive Fc-containing proteins.
• April 2021 - Thermo Fisher Scientific introduced the KingFisher Apex Purification System. It is a large sample purification apparatus designed for scientists that need to automate the separation of DNA, proteins, and cells from a variety of sample types. The KingFisher Apex purifying system allows users to isolate proteins and cells while also customizing methods.

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Protein Purification & Isolation Market: Regional Landscape

Increasing use of drug screening procedures is likely to help North America dominate the global market

North America dominates the global protein purification & isolation market and accounted for more than 45% of the global revenue in 2021. The region's increased use of drug screening procedures is propelling the industry forward. High funding for life science research, a developed research infrastructure, and the presence of major elements is increasing protein purification & isolation sales in the area. The growth in biopharmaceutical drug development in the United States is another factor likely to drive the regional protein purification & isolation market over the forecast period. Improving application areas, including protein-protein interaction studies, detection and tracking, drug screening, protein treatments, biomarker discovery, sickness tracking, and diagnostic imaging are boosting demand for technologically upgraded protein purification & isolation technologies in North America.

The Asia Pacific regional market is expected to expand the fastest during the forecast period. Initiatives launched by developing-country governments like China and India to strengthen healthcare facilities are expected to stimulate the market demand in the region. Additionally, these countries contribute funds to developing novel protein purification & isolation procedures. As a result, Japan, India, and China are the dominant countries in the Asia Pacific, providing enormous chances for the market's main players to grow and keep up with trends to deliver profitable outcomes.

Competitive Landscape

Some of the main competitors dominating the global protein purification & isolation market include - Thermo Fischer Scientific Inc., GE Healthcare Life Sciences, Merck KGaA, Qiagen N.V., Sigma-Aldrich Corporation, Bio-Rad Laboratories Inc., Promega Corporation, Abcam, Roche Applied Science, and Agilent Technologies.

Global protein purification & isolation market is segmented as follows:

By Product Outlook

• Instruments
• Consumables

By Technology Outlook

• Ultrafiltration
• Precipitation
• Chromatography
• Electrophoresis
• Western Blotting
• Others

By Application Outlook

• Drug Screening
• Biomarker Discovery
• Protein-protein Interaction Studies
• Diagnostics

By End-use Outlook

• Academic and Research Institutes
• Hospitals
• Pharmaceutical and Biotechnological Companies
• CROs

By Region

• North America
  • The U.S.
  • Canada
• Europe
  • France 
  • The UK
  • Spain
  • Germany
  • Italy
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • South Korea
  • Southeast Asia
  • Rest of Asia Pacific
• Latin America
  • Brazil
  • Mexico
  • Rest of Latin America
• Middle East & Africa
  • GCC
  • South Africa
  • Rest of Middle East & Africa