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Human Microbiome Market - Global Industry Analysis

Human Microbiome Market - By Product (Probiotics, Prebiotics, Medical Foods, and Supplements), By Application (Therapeutics And Diagnostics) And By Disease Type (Obesity, Diabetes, Autoimmune Disorder, Metabolic & Gastrointestinal Disorders, and Cancer): Global Industry Perspective, Comprehensive Analysis And Forecast, 2021 – 2028

Published Date: 30-Nov-2021 Category: Healthcare Report Format : PDF Pages: 157 Report Code: ZMR-1473 Status : Published

Global human microbiome market expected to generate revenue of around USD 1,365.49 million by the end of 2024, growing at a CAGR of around 9.40% between 2018 and 2024. The human microbiome is the genetic material of microbes such as bacteria, protozoa, viruses, and fungi which are present in or on a human body.

Description

The global Human Microbiome Market accrued earnings worth approximately 750 (USD Million) in 2020 and is predicted to gain revenue of about 1,597 (USD Million) by 2028, is set to record a CAGR of nearly 9.40% over the period from 2021 to 2028. The report offers assessment and analysis of the Human Microbiome Market on a global and regional level. The study offers a comprehensive assessment of the market competition, constraints, revenue estimates, opportunities, evolving trends, and industry-validated data. The report provides historical data from 2018 to 2020 along with a forecast from 2021 to 2028 based on revenue (USD Million).

Human Microbiome Market: Outlook

Human microbiome consists of viruses, archaea, eukaryotes, and bacteria residing inside as well as outside of human body at various sites. Furthermore, human microbiome is referred as genomic content of microorganisms that inhabits a particular location in human body system such as skin, gastrointestinal tract, mammary gland, respiratory tract, mucosa, and urogenital tract. Moreover, these microbes affect human physiology contributing towards improvement as well as impairment of both immune & metabolic activities during good health & disorders. Rapid development of sequence and analytical methods are increasing our ability in understanding human microbiome working and its constituents.  Moreover, human microbiota comprises of 10 to 100 trillion symbiotic microbial tissue cells that are harbored by each individual and human microbiome comprises of genes of these microbial tissue cells harbor.

Report Scope:

Report Attribute Details
Base Year 2020
Historic Years 2016 - 2020
Forecast Years 2021 - 2028
Segments Covered By Product Type, By Application, and By End Use
Forecast Units Value (USD Billion), and Volume (Units)
Quantitative Units Revenue in USD million/billion and CAGR from 2021 to 2028
Regions Covered North America, Europe, Asia Pacific, Latin America, and Middle East & Africa, and Rest of World
Countries Covered U.S., Canada, Mexico, U.K., Germany, France, Italy, Spain, China, India, Japan, South Korea, Brazil, Argentina, GCC Countries, and South Africa, among others
Number of Companies Covered 10 companies with scope for including additional 15 companies upon request
Report Coverage Market growth drivers, restraints, opportunities, Porter’s five forces analysis, PEST analysis, value chain analysis, regulatory landscape, market attractiveness analysis by segments and region, company market share analysis, and COVID-19 impact analysis.
Customization Scope Avail customized purchase options to meet your exact research needs.

For the record, studies of diverse human microbiome commenced with Antonie Van Leewenhoek. Reportedly, he in 1680s compared his own fecal with his oral microbiota and found huge differences in microbes of both. Moreover, he also found profound differences between samples of two habitats taken from large number of population. Moreover, in modern times, not only these differences are measured by using various techniques, but some strong powerful methods such as molecular techniques are developed in understanding the differences existing between two habitats as well as gain insights into how one can impact transformation from one state to other state.  

Human Microbiome Market: Growth Factors

Breakthroughs in sequencing techniques & understanding of microbiome are projected to provide insights into microbiota and thereupon decide on personalized medicine treatment for each individual based on the extracted microbiota information. This is predicted to create new growth opportunities for human microbiome market in near future. Furthermore, microbiome ventures are launched across globe with an aim of knowing roles played by symbionts as well as their impact on health of human beings, thereby driving industry trends. Understanding human microbiome helps in garnering information about presence of cancer tissues as well as identifying inflammatory bowel disease causing viruses and allergy causing microbes.

Furthermore, human microbiome plays a key role in development & maintenance of human body. Moreover, these microorganisms hold a key to development of immune system & hosts nutrition, homeostasis maintenance, and colonization resistance as well as immune regulation in young children and neonates. Major role played by microbiome in human health development will prompt growth of human microbiome market over forecasting timeframe. Furthermore, human microbiome is a major source of genetic diversity, disease modifier, a key immunity component, and functional entity influencing body metabolism and modulating medicine interactions. Moreover, examination of human microbiome has been highly influenced due to breakthroughs taking place in genome technologies. Additionally, developments witnessed in biotechnology domain and particularly in genome field have helped researchers to delve deep into human microbiome studies and gain comprehensive understanding about its findings.

Regional Insights

North America To Contribute Majorly Towards Human Microbione Market Size By 2028

Growth of regional market over forecast timespan is subject to amplicon-based surveys carried on human microbial communities and microbial genome sequencing & whole-genome shotgun metagenomic sequencing activities in various reputed biotech firms based in the U.S. In addition to this, presence of giant biotech players in the countries such as Canada and the U.S. will contribute lucratively towards regional market size. Growing focus on human microbiome drug development and launching of new kinds of antibiotics for treating disease after studying human microbiome in the U.S. labs will steer growth of human microbiome market in sub-continent.

Competitive Insights

Key players favorably impacting growth of human microbione market and profiled in study are Rebiotix, Inc., Osel, Inc., OBiome LLC, Vedanta Biosciences, Second Genome, Seres Therapeutics, Enterome Biosciences, Metabiomics Corp., uBiome, Inc., and Synthetic Biologics, Inc. 

The global Human Microbiome Market is segmented as follows:

By Product

  • Probiotics
  • Prebiotics
  • Medical Foods
  • Supplements

By Disease Type

  • Obesity
  • Diabetes
  • Autoimmune Disorder
  • Metabolic & Gastrointestinal Disorders
  • Cancer

By Application

  • Therapeutics
  • Diagnostics

By Region

  • North America
    • The U.S.
    • Canada
  • Europe
    • France
    • The UK
    • Spain
    • Germany
    • Italy
    • Rest of Europe
  • Asia Pacific
    • China
    • Japan
    • India
    • South Korea
    • Southeast Asia
    • Rest of Asia Pacific
  • Latin America
    • Brazil
    • Mexico
    • Rest of Latin America
  • Middle East & Africa
    • GCC
    • South Africa
    • Rest of Middle East & Africa

Table Of Content

  • Chapter 1. Preface
    • 1.1. Report Description and Scope
    • 1.2. Research Scope
    • 1.3. Research Methodulogy
      • 1.3.1. Market Research Type
      • 1.3.2. Market Research Methodulogy
  • Chapter 2. Executive Summary
    • 2.1. Higher Education Market, 2018–2028(USD Million)
    • 2.2. Higher Education Market: Snapshot
  • Chapter 3. Global Higher Education Market– Industry Analysis
    • 3.1. Higher Education Market: Market Dynamics
    • 3.2. Market Drivers
      • 3.2.1. Human microbiome is a key source of genetic diversity, disease modifier, a key immunity product, and functional unit impacting body metabulism and modifying drug interactions. This, in turn, will create lucrative avenues of growth for human microbiome industry in forthcoming years.
      • 3.2.2. Assessment of human microbiome has been highly influenced owing to breakthroughs taking place in genome technulogies, thereby enlarging scope of growth of human microbiome market.
    • 3.3. Porter’s Five Forces Analysis
    • 3.4. Market Attractiveness Analysis
      • 3.4.1. Market attractiveness analysis By Product
      • 3.4.2. Market attractiveness analysis By Application
      • 3.4.3. Market attractiveness analysis By Disease Type
  • Chapter 4. Global Higher Education Market– Competitive Landscape
    • 4.1. Company market share analysis
      • 4.1.1. Global Higher Education Market: company market share, 2019
    • 4.2. Strategic development
      • 4.2.1. Acquisitions & mergers
      • 4.2.2. New Product launches
      • 4.2.3. Agreements, partnerships, cullaborations, and joint ventures
      • 4.2.4. Research and development and Regional expansion
    • 4.3. Price trend analysis
  • Chapter 5. Global Higher Education Market– Product Analysis
    • 5.1. Global Human Microbiome Marketoverview: By Product
      • 5.1.1. Global Human Microbiome Marketshare, By Product, 2020 and 2028
    • 5.2. Probiotics
      • 5.2.1. Global Higher Education Marketby Probiotics, 2018–2028(USD Million)
    • 5.3. Prebiotics
      • 5.3.1. Global Higher Education Marketby Prebiotics, 2018–2028(USD Million)
    • 5.4. Medical Foods
      • 5.4.1. Global Higher Education Marketby Medical Foods, 2018–2028(USD Million)
    • 5.5. Supplements
      • 5.5.1. Global Higher Education Marketby Supplements, 2018–2028(USD Million)
  • Chapter 6. Global Higher Education Market– Application Analysis
    • 6.1. Global Higher Education Marketoverview: By Application
      • 6.1.1. Global Higher Education Marketshare, By Application, 2020 and 2028
    • 6.2. Therapeutics
      • 6.2.1. Global Higher Education Marketby Therapeutics , 2018–2028(USD Million)
    • 6.3. Diagnostics
      • 6.3.1. Global Higher Education Marketby Diagnostics, 2018–2028(USD Million)
  • Chapter 7. Global Higher Education Marketoverview: By Disease Type
    • 7.1. Global Higher Education Marketshare, By Disease Type , 2020 and 2028
    • 7.2. Obesity
      • 7.2.1. Global Higher Education Marketby Obesity, 2018–2028(USD Million)
    • 7.3. Diabetes
      • 7.3.1. Global Higher Education Marketby Diabetes, 2018–2028(USD Million)
    • 7.4. Autoimmune Disorder
      • 7.4.1. Global Higher Education Marketby Autoimmune Disorder, 2018–2028(USD Million)
    • 7.5. Metabulic & Gastrointestinal Disorders
      • 7.5.1. Global Higher Education Marketby Metabulic & Gastrointestinal Disorders, 2018–2028(USD Million)
    • 7.6. Cancer
      • 7.6.1. Global Higher Education Marketby Cancer, 2018–2028(USD Million)
  • Chapter 8. Company Profiles
    • 8.1. Rebiotix, Inc.
      • 8.1.1. Overview
      • 8.1.2. Financials
      • 8.1.3. Product Portfulio
      • 8.1.4. Business Strategy
      • 8.1.5. Recent Developments
    • 8.2. Osel, Inc.
      • 8.2.1. Overview
      • 8.2.2. Financials
      • 8.2.3. Product Portfulio
      • 8.2.4. Business Strategy
      • 8.2.5. Recent Developments
    • 8.3. OBiome LLC
      • 8.3.1. Overview
      • 8.3.2. Financials
      • 8.3.3. Product Portfulio
      • 8.3.4. Business Strategy
      • 8.3.5. Recent Development
    • 8.4. Vedanta Biosciences
      • 8.4.1. Overview
      • 8.4.2. Financials
      • 8.4.3. Product Portfulio
      • 8.4.4. Business Strategy
      • 8.4.5. Recent Development
    • 8.5. Second Genome
      • 8.5.1. Overview
      • 8.5.2. Financials
      • 8.5.3. Product Portfulio
      • 8.5.4. Business Strategy
      • 8.5.5. Recent Development
    • 8.6. Seres Therapeutics
      • 8.6.1. Overview
      • 8.6.2. Financials
      • 8.6.3. Product Portfulio
      • 8.6.4. Business Strategy
      • 8.6.5. Recent Development
    • 8.7. Enterome Biosciences
      • 8.7.1. Overview
      • 8.7.2. Financials
      • 8.7.3. Product Portfulio
      • 8.7.4. Business Strategy
      • 8.7.5. Recent Development
    • 8.8. Metabiomics Corp.
      • 8.8.1. Overview
      • 8.8.2. Financials
      • 8.8.3. Product Portfulio
      • 8.8.4. Business Strategy
      • 8.8.5. Recent Development
    • 8.9. uBiome, Inc.
      • 8.9.1. Overview
      • 8.9.2. Financials
      • 8.9.3. Product Portfulio
      • 8.9.4. Business Strategy
      • 8.9.5. Recent Development
    • 8.10. Synthetic Biulogics, Inc.
      • 8.10.1. Overview
      • 8.10.2. Financials
      • 8.10.3. Product Portfulio
      • 8.10.4. Business Strategy
      • 8.10.5. Recent Development

List of Figures

1. Market research Type
2. Market research methodology
3. Global Higher Education Market, 2018–2028(USD Million)
4. Porter’s Five Forces Analysis
5. Global Higher Education Marketattractiveness, By Product
6. Global Higher Education Marketattractiveness, By Application
7. Global Higher Education Marketattractiveness, By Disease Type
8. Global Higher Education Marketshare by Product ,2020 and 2028 (USD Million)
9. Global Higher Education Marketby Probiotics, 2018–2028(USD Million)
10. Global Higher Education Marketby Prebiotics, 2018–2028(USD Million)
11. Global Higher Education Marketby Medical Foods, 2018–2028(USD Million)
12. Global Higher Education Marketby Supplements, 2018–2028(USD Million)
13. Global Higher Education Marketshare by Application,2020 and 2028 (USD Million)
14. Global Higher Education Marketby Therapeutics,  2018–2028(USD Million)
15. Global Higher Education Marketby Diagnostics, , 2018–2028(USD Million)
16. Global Higher Education Marketshare by Disease Type ,2020 and 2028 (USD Million)
17. Global Higher Education Marketby Obesity, 2018–2028(USD Million)
18. Global Higher Education Marketby Diabetes, 2018–2028(USD Million)
19. Global Higher Education Marketby Autoimmune Disorder, 2018–2028(USD Million)
20. Global Higher Education Marketby Metabolic & Gastrointestinal Disorders, 2018–2028(USD Million)
21. Global Higher Education Marketby Cancer, 2018–2028(USD Million)
22. Global Higher Education Marketshare, by Region, 2020 and 2028
23. North America Higher Education Market, 2018–2028(USD Million)
24. Europe Higher Education Market, 2018–2028(USD Million)
25. Asia Pacific Higher Education Market, 2018–2028(USD Million)
26. Latin America Higher Education Market, 2018–2028(USD Million)
27. The Middle East and Africa Higher Education Market, 2018–2028(USD Million)
 


List of Tables

1. Global Higher Education Market: snapshot
2. Drivers of the Higher Education Market: impact analysis
3. North America Human Microbiome Marketrevenue, By Product  ,2018–2028(USD Million)
4. North America Human Microbiome Marketrevenue, By Application ,2018–2028(USD Million)
5. North America Human Microbiome Marketrevenue, By Disease Type ,2018–2028(USD Million)
6. The U.S. Human Microbiome Marketrevenue, By Product  ,2018–2028(USD Million)
7. The U.S. Human Microbiome Marketrevenue, By Application ,2018–2028(USD Million)
8. The U.S. Human Microbiome Marketrevenue, By Disease Type ,2018–2028(USD Million)
9. Rest of North America Human Microbiome Marketrevenue, By Product  ,2018–2028(USD Million)
10. Rest of North America Human Microbiome Marketrevenue, By Application ,2018–2028(USD Million)
11. Rest of North America Human Microbiome Marketrevenue, By Disease Type ,2018–2028(USD Million)
12. Europe Human Microbiome Marketrevenue, By Product  ,2018–2028(USD Million)
13. Europe Human Microbiome Marketrevenue, By Application ,2018–2028(USD Million)
14. Europe Human Microbiome Marketrevenue, By Disease Type ,2018–2028(USD Million)
15. UK Human Microbiome Marketrevenue, By Product  ,2018–2028(USD Million)
16. UK Human Microbiome Marketrevenue, By Application ,2018–2028(USD Million)
17. UK Human Microbiome Marketrevenue, By Disease Type ,2018–2028(USD Million)
18. France Human Microbiome Marketrevenue, By Product  ,2018–2028(USD Million)
19. France Human Microbiome Marketrevenue, By Application ,2018–2028(USD Million)
20. France Human Microbiome Marketrevenue, By Disease Type ,2018–2028(USD Million)
21. Germany Human Microbiome Marketrevenue, By Product  ,2018–2028(USD Million)
22. Germany Human Microbiome Marketrevenue, By Application ,2018–2028(USD Million)
23. Germany Human Microbiome Marketrevenue, By Disease Type ,2018–2028(USD Million)
24. Rest of Europe Human Microbiome Marketrevenue, By Product  ,2018–2028(USD Million)
25. Rest of Europe Human Microbiome Marketrevenue, By Application ,2018–2028(USD Million)
26. Rest of Europe Human Microbiome Marketrevenue, By Disease Type ,2018–2028(USD Million)
27. Asia Pacific Human Microbiome Marketrevenue, By Product  ,2018–2028(USD Million)
28. Asia Pacific Human Microbiome Marketrevenue, By Application ,2018–2028(USD Million)
29. Asia Pacific Human Microbiome Marketrevenue, By Disease Type ,2018–2028(USD Million)
30. China Human Microbiome Marketrevenue, By Product  ,2018–2028(USD Million)
31. China Human Microbiome Marketrevenue, By Application ,2018–2028(USD Million)
32. China Human Microbiome Marketrevenue, By Disease Type ,2018–2028(USD Million)
33. Japan Human Microbiome Marketrevenue, By Product  ,2018–2028(USD Million)
34. Japan Human Microbiome Marketrevenue, By Application ,2018–2028(USD Million)
35. Japan Human Microbiome Marketrevenue, By Disease Type ,2018–2028(USD Million)
36. India Human Microbiome Marketrevenue, By Product  ,2018–2028(USD Million)
37. India Human Microbiome Marketrevenue, By Application ,2018–2028(USD Million)
38. India Human Microbiome Marketrevenue, By Disease Type ,2018–2028(USD Million)
39. Rest of Asia Pacific Human Microbiome Marketrevenue, By Product  ,2018–2028(USD Million)
40. Rest of Asia Pacific Human Microbiome Marketrevenue, By Application ,2018–2028(USD Million)
41. Rest of Asia Pacific Human Microbiome Marketrevenue, By Disease Type ,2018–2028(USD Million)
42. Latin America Human Microbiome Marketrevenue, By Product  ,2018–2028(USD Million)
43. Latin America Human Microbiome Marketrevenue, By Application ,2018–2028(USD Million)
44. Latin America Human Microbiome Marketrevenue, By Disease Type ,2018–2028(USD Million)
45. Brazil Human Microbiome Marketrevenue, By Product  ,2018–2028(USD Million)
46. Brazil Human Microbiome Marketrevenue, By Application ,2018–2028(USD Million)
47. Brazil Human Microbiome Marketrevenue, By Disease Type ,2018–2028(USD Million)
48. Rest of Latin America Human Microbiome Marketrevenue, By Product  ,2018–2028(USD Million)
49. Rest of Latin America Human Microbiome Marketrevenue, By Application ,2018–2028(USD Million)
50. Rest of Latin  America Human Microbiome Marketrevenue, By Disease Type ,2018–2028(USD Million)
51. The Middle East and Africa Human Microbiome Marketrevenue, By Product  ,2018–2028(USD Million)
52. The Middle East and Africa Human Microbiome Marketrevenue, By Application ,2018–2028(USD Million)
53. The Middle East and Africa Human Microbiome Marketrevenue, By Disease Type ,2018–2028(USD Million)
54. Saudi Arabia Human Microbiome Marketrevenue, By Product  ,2018–2028(USD Million)
55. Saudi Arabia Human Microbiome Marketrevenue, By Application ,2018–2028(USD Million)
56. Saudi Arabia Human Microbiome Marketrevenue, By Disease Type ,2018–2028(USD Million)
57. South Africa Human Microbiome Marketrevenue, By Product  ,2018–2028(USD Million)
58. South Africa Human Microbiome Marketrevenue, By Application ,2018–2028(USD Million)
59. South Africa Human Microbiome Marketrevenue, By Disease Type ,2018–2028(USD Million)
60. Rest of the Middle East & Africa Human Microbiome Marketrevenue, By Product  ,2018–2028(USD Million)
61. Rest of the Middle East & Africa Human Microbiome Marketrevenue, By Application ,2018–2028(USD Million)
62. Rest of the Middle East & Africa Human Microbiome Marketrevenue, By Disease Type ,2018–2028(USD Million)

           
 


 

Methodology

Free Analysis

The human microbiome is the full array of the microbiota (microorganisms) that reside in or on the human body. Specifically, these are the collection of the genomes of microbes that contribute to the metagenome, i.e., a genetic portrait of humans.

According to the CDC, in 2015-16, over 93.3 million adults in the U.S. were obese. The human microbiome helps the body to improve the digestion system due to which the metabolic activities increases. These help the obese people to control the weight & initiate their weight loss. The rapid awareness about the use of human microbiome to treat diseases like diabetes, autoimmune disorders, obesity, etc. is fueling the growth of the global human microbiome market. Also, increased research in this field, use of human microbiome for drug development, and need of early diagnosis of various diseases are expected to drive the growth of the global human microbiome market.

Global-Human-Microbiome-Market

Human microbiome market is segmented on the basis of product, application, and disease type. Based on the product, the human microbiome market is further segmented into prebiotics, probiotics, medical foods, supplements, & others. Probiotics segment is anticipated to dominate the product segment of the human microbiome market. The growth in awareness about the beneficial properties of prebiotics is expected to fuel the growth of the prebiotics segment. Based on application, the human microbiome market is further segmented into therapeutics application & diagnostics application. The increase in research yielding new applications and usage of the human microbiome is expected to fuel the growth of the therapeutic market. The disease type segment is further segmented into obesity, diabetes, an autoimmune disorder, metabolic & gastrointestinal disorders, cancer & other diseases. Metabolic & gastrointestinal diseases segment is expected to dominate the market in the forecast period due to rise in awareness about the use of human microbiome in the treatment of metabolic & gastrointestinal diseases.

North America is anticipated to dominate the human microbiome market in the forecast period due to the increase in the number of ongoing clinical trials, increase in the prevalence of a disease such as diabetes & cancer, and early adoption of recently developed technologies. The Asia Pacific is expected to show the highest growth rate in the forecast period due to rapid awareness about the benefits of the human microbiome & rapid development & innovations in the research. Also, increase in a number of initiatives that aims to optimize the method for studying the effect of the gut microbiome on human health through the various protocols and procedures is anticipated to fuel the growth of Asia Pacific market.

The main players involved in the global human microbiome market are AOBiome LLC, Second Genome, Seres Therapeutics, Osel, Inc., Metabiomics Corp., uBiome, Inc., Rebiotix, Inc., Enterome Biosciences, Vedanta Biosciences, and Synthetic Biologics, Inc. The major companies are focusing on providing the microbiomes which are useful for the treatment of different diseases & disorders. For instance, in April 2018, AOBiome Therapeutics, initiated a clinical trial for Ammonia-Oxidizing Bacteria to treat an Episodic Migraine.

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FrequentlyAsked Questions

Breakthroughs in sequencing techniques & understanding of microbiome are projected to provide insights into microbiota and thereupon decide on personalized medicine treatment for each individual based on the extracted microbiota information. This is predicted to create new growth opportunities for human microbiome market in near future. Furthermore, microbiome ventures are launched across globe with an aim of knowing roles played by symbionts as well as their impact on health of human beings, thereby driving industry trends. Understanding human microbiome helps in garnering information about presence of cancer tissues as well as identifying inflammatory bowel disease causing viruses and allergy causing microbes.

Furthermore, human microbiome plays a key role in development & maintenance of human body. Moreover, these microorganisms hold a key to development of immune system & hosts nutrition, homeostasis maintenance, and colonization resistance as well as immune regulation in young children and neonates. Major role played by microbiome in human health development will prompt growth of human microbiome market over forecasting timeframe.   

According to Zion market research report, the global Human Microbiome Market accrued earnings worth approximately 750 (USD Million) in 2020 and is predicted to gain revenue of about 1,597 (USD Million) by 2028, is set to record a CAGR of nearly 9.40% over the period from 2021 to 2028.

 

North America will contribute lucratively towards the global market earnings over the projected timeline. The regional market surge is subject to amplicon-based surveys carried on human microbial communities and microbial genome sequencing & whole-genome shotgun metagenomic sequencing activities in various reputed biotech firms based in the U.S. In addition to this, presence of giant biotech players in the countries such as Canada and the U.S. will contribute lucratively towards regional market size. Growing focus on human microbiome drug development and launching of new kinds of antibiotics for treating disease after studying human microbiome in the U.S. labs will steer growth of human microbiome market in sub-continent.

The key market participants include Rebiotix, Inc., Osel, Inc., OBiome LLC, Vedanta Biosciences, Second Genome, Seres Therapeutics, Enterome Biosciences, Metabiomics Corp., uBiome, Inc., and Synthetic Biologics, Inc. 

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