Protein A Resin Market Size, Share, Trends, Growth and Forecast 2030

Protein A Resin Market Industry Prospective

According to the report published by Zion Market Research, the Global Protein A Resin Market size was valued at USD 680.78 Million in 2023 and is predicted to reach USD 2215.00 Million by the end of 2032. The market is expected to grow with a CAGR of 15.89% during the forecast period. The report analyzes the Global Protein A Resin Market’s growth drivers, restraints, and impact on demand during the forecast period. It will also help navigate and explore the arising opportunities in the Protein A Resin Market industry.

Request Free Sample

Global Protein A Resin Market: Overview

Protein A resin is utilized in the immunoprecipitation of protein, antigens, or protein complexes. Protein A is a kind of bacteria cell wall separated from the class of Staphylococcus aureus that has the ability to bind with the mammalian IgGs majorly from FC regions. Native protein A comprises major 5 IgG binding domains. Recombinant protein also has 5 high-affinity IgG binding domains. Protein A resin is extensively utilized in analyzing contaminated products. Protein A resin chromatography is largely utilized in purifying the materials. Chromatography is being used as a substitute for enhancing the productivity of resin capability of the chromatography purifying process. Protein A resin is also adopted in the affinity resins in bio-manufacturing.

Key Insights:

• As per the analysis shared by our research analyst, the global protein A resin market is estimated to grow annually at a CAGR of around 15.89% over the forecast period (2023-2030)
• In terms of revenue, the global protein A resin market tsize was valued at around USD 680.78 Million in 2022 and is projected to reach USD 2215 Million by 2030.
• Based on the End-user, the pharmaceutical & biopharmaceutical company segment is expected to lead the market, while the wheat segment is expected to grow considerably.
• Based on Application, the immunoprecipitation and antibody purification segment is the dominating segment, while the domestic consumers segment is projected to witness sizeable revenue over the forecast period.
• Based on Type, the natural protein A and recombinant protein A segment is the dominating segment, while the domestic consumers segment is projected to witness sizeable revenue over the forecast period.
• Based on Product, the organic polymer-based protein A, silica-based protein A, and agarose-based protein A segment is the dominating segment, while the domestic consumers segment is projected to witness sizeable revenue over the forecast period.
• Based on region, North America is projected to dominate the global market during the estimated period, followed by Asia Pacific.

Global Protein A Resin Market: Growth Factors

The surging investments in synthetic biology and constant emphasis on drug development by pharmaceutical and biotechnology companies are likely to drive the growth of the global protein A resin market exponentially in the forthcoming years. Furthermore, pharmaceutical companies are highly utilizing protein engineering products in research projects to develop a wide range of protein-based drugs. Thereby, the growing use of chromatography in the process of drug discovery and research will fuel the market growth significantly. However, researchers and scientists have a keen interest in synthetic biology. They are trying to build a noble machine that can efficiently generate synthetic proteins. Moreover, there is a high prevalence of chronic diseases all across the globe which is significantly stressing pharmaceutical companies and government authorities to focus on developing novel therapeutics for disease management.

Also, there is high demand for monoclonal antibodies for treating a wide range of chronic diseases. During the purification process, the anionic impurities in monoclonal antibodies like endotoxin and nucleic acids are eliminated with the help of chromatography. During the drug discovery applications, the purification process utilizes huge amount of resins. Impurities like transferrin and albumin can also be eliminated with the help of size exclusion chromatography. A higher extent of purification can be achieved with the help of protein A affinity resins because the antibodies bind the protein A ligands selectively with resins. However, such emerging landscapes are likely to expedite the growth of the global protein A resin market over the forecast period.

Request Free Sample

Global Protein A Resin Market: Segmentation

The global protein A resin market can be segmented into end-user, application, type, product, and region.

By End-user, the market can be segmented into academic research institutes, pharmaceutical & biopharmaceutical companies, and others. The pharmaceutical & biopharmaceutical company segment accounts for the largest share in the global protein A resin market. The growth can be attributed to the growing expenditure in the pharmaceutical and biopharmaceutical sectors for fueling their research and development activities for the launch of unique products in the market.

By Application, the market can be segmented into immunoprecipitation and antibody purification. The antibody purification segment dominates the global protein A resin market due to the growing demand for monoclonal antibodies for research and therapeutic purposes.

By Type, the market can be segmented into natural protein A and recombinant protein A.

By Product, the market can be segmented into organic polymer-based protein A, silica-based protein A, and agarose-based protein A. The agarose-based protein A segment holds hegemony over others due to its wide utilization for binding ligands and protein.

Recent Developmentst

• At BIO 2024, a next-gen Protein A resin, DurA Cycle A50, was introduced by Purolite, updated for supply-chain resilience, sustainability, and manufacturing excellence, on account of its patented “Jetting” bead technology for lot-to-lot consistency.
• In September 2021, Avitide Inc. was acquired by Repligen Corporation $75 million in stock plus $150 million in cash, firming its abilities in affinity ligand development and discovery—vital to its Protein A resin offerings. 

Protein A Resin Market: Report Scope

Protein A Resin Market: Dynamics

Key Growth Drivers

The market for Protein A Resin is significantly driven by the increasing global demand for monoclonal antibodies (mAbs) and other therapeutic proteins. As the biopharmaceutical industry expands, particularly in the areas of oncology and autoimmune diseases, there is a heightened need for efficient and high-purity purification methods. Protein A resins are considered the "gold standard" for purifying mAbs due to their high specificity and efficiency, making them a critical component in the manufacturing process. A rise in R&D activities and investments in the biopharmaceutical sector, coupled with the growing production of biosimilars, further propels the demand for these resins.

Restraints

One of the primary restraints for the Protein A Resin market is the high cost associated with these chromatography media. Protein A resins are considerably more expensive than other types of resins, and this cost can be a significant barrier for smaller biotech companies or academic research laboratories with limited budgets. Additionally, the resins have a limited number of purification cycles before their binding capacity diminishes, requiring frequent replacement and adding to the overall operational expenditure. This high cost and limited reusability can lead companies to explore alternative purification methods, especially in cost-sensitive emerging markets.

Opportunities

The market presents attractive opportunities for innovation and growth. There is a growing demand for the development of high-capacity and alkali-stable Protein A ligands, which can withstand harsher cleaning conditions and be reused for more cycles, thereby improving cost-effectiveness. The increasing adoption of continuous bioprocessing systems and single-use technologies in biopharmaceutical manufacturing also creates a need for compatible Protein A resins. Furthermore, the expansion of biopharmaceutical manufacturing in emerging economies, particularly in the Asia-Pacific region, offers a significant growth avenue for market players.

Challenges

The Protein A Resin market faces several challenges. Supply chain limitations and fluctuations in raw material prices can impact production and lead to increased costs and potential shortages. The manufacturing process itself is complex, requiring specialized expertise and facilities, which can be a barrier for new entrants. Regulatory hurdles and the need to adhere to stringent quality control standards also pose a challenge for manufacturers. Additionally, the emergence of alternative purification technologies could present a competitive threat to the dominance of traditional Protein A resins.

Global Protein A Resin Market: Regional analysis

North America accounts for the largest share in the global protein A resin market due to the growing research and development activities undertaken by pharmaceutical companies and research institutes. Also, the surge in demand for monoclonal antibodies for treating the surging prevalence of chronic diseases is likely to further accentuate the growth of the regional market. However, the wide adoption of chromatographic techniques for purifying and identifying biochemicals, which in turn will also steer the growth significantly. In addition, the high prevalence of autoimmune diseases is supporting the growth of the regional market by demanding effective treatment methods.

Asia Pacific is expected to witness a significant growth rate in forthcoming years due to the presence of prominent market leaders in the region. Also, the fast proliferating biopharmaceutical and pharmaceutical sector in the region is another key factor promulgating the growth of the regional market. However, the growing government initiatives are likely to open several lucrative growth opportunities in the regional market. Also, the adoption of protein A resins for the purification process due to the fact that it helps in achieving excellent grade purity will also expedite the growth of the regional market.

Request Free SampleRequest Free Sample

Global Protein A Resin Market: Competitive Players

Some of the significant players in the global protein A resin market are:

• Takara Bio Inc.
• Amikozen Co. Ltd.
• Bio-Works Technologies
• JSR Life Sciences
• Avantor
• Agarose Bead Technologies
• Abcam
• Kaneka Corporation
• Orochem
• Bio-Rad Laboratories
• PerkinElmer
• GenScript Biotech Corporation
• Agilent Technologies
• Novasep Holding SAS
• Purolite Corporation
• Tosoh Bioscience
• Thermo Fisher Scientific
• Repligen Corporation
• Merck Millipore
• GE Healthcare.

The Global Protein A Resin Market is segmented as follows:

By End-user 

• Academic Research Institutes
• Pharmaceutical & Biopharmaceutical Companies
• Others

By Application 

• Immunoprecipitation
• Antibody Purification 

By Type 

• Natural Protein A
• Recombinant Protein A

By Product 

• Organic Polymer-Based Protein A
• Silica-Based Protein A
• Agarose-Based Protein A

Global Protein A Resin Market: Regional Segment Analysis

• North America
  • The U.S.
  • Canada
• Europe
  • France
  • The UK
  • Spain
  • Germany
  • Italy
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • South Korea
  • Southeast Asia
  • Rest of Asia Pacific
• Latin America
  • Brazil
  • Mexico
  • Rest of Latin America
• Middle East & Africa
  • GCC
  • South Africa
  • Rest of Middle East & Africa

What Reports Provides

• Full in-depth analysis of the parent market
• Important changes in market dynamics
• Segmentation details of the market
• Former, on-going, and projected market analysis in terms of volume and value
• Assessment of niche industry developments
• Market share analysis
• Key strategies of major players
• Emerging segments and regional markets
• Testimonials to companies in order to fortify their foothold in the market.