Global Downstream Processing Market to Grow Around USD 88.6 Billion By 2030

06-Feb-2023 | Zion Market Research

The global downstream processing market size was worth around USD 26.2 Billion in 2021 and is predicted to grow to around USD 88.6 Billion by 2030 with a compound annual growth rate (CAGR) of roughly 14.5% between 2022 and 2030.

Downstream processing is a process wherein purification is done and the biosynthetic products are recovered especially the pharmaceuticals that are obtained from natural sources. The downstream processing includes five stages that are solid-liquid separation, intracellular products are released, and concentration & chromatography method is used for purification and formulation. Solid-liquid separation method involves methods such as centrifugation, flocculation, flotation, and filtration.

The major factor that contributes to the growth of the global downstream processing market is the rising demand for biopharmaceutical products. This is because downstream processing plays an important role in providing completely pure biopharmaceutical products of high quality. Moreover, the increasing investments that are being made in the research and development of biopharmaceuticals drive the demand of the market. On the other hand, the patent expiration of popular biopharmaceuticals expects to open up new lucrative opportunities that will contribute to the growth of the market.

Emerging markets of regions such as Asia-Pacific are likely to provide new market opportunities that will drive the growth of the downstream processing industry. However, certain factors are hampering the market growth which includes a lack of skilled & experienced people and the high economy that is involved in installing the instruments. In addition, the lack of single-use options and purification bottlenecks are challenging the market growth.

Global Downstream Processing Market

The global downstream processing market is segmented based on product, technique, application, and region.

Based on the product, the global market is bifurcated into chromatography systems, filters, evaporators, centrifuges, dryers, and others. The chromatography systems segment accounted for the largest market share in 2021 and is expected to show its dominance during the forecast period. Growth of the segment is predicted to be fueled by ongoing R&D efforts to increase the effectiveness and speed of chromatography systems.

Thermo Fisher Scientific introduced the HyPeak chromatography system in April 2021; it is the only single-use chromatography system for bioprocessing offered by the company and plays a vital role in the creation of therapeutic proteins and vaccines. The growth of the industry is further aided by an increase in chromatography system deals and innovations. For instance, Sartorius Stedim Biotech announced in January 2021 that it had acquired the chromatography equipment business from Novasep. Thus, the product launch and the ongoing acquisition will further fuel the market expansion over the forecast period.

Based on the technique, the market is bifurcated into cell disruption, solid-liquid separation, concentration, purification by chromatography, and formulation. Purification by chromatography is expected to dominate the market over the forecast period. In downstream bioprocessing, single-use chromatography and filtering systems are regarded as the gold standards. As a result, businesses are pursuing business expansion tactics including acquisition, merger, and agreement to broaden their chromatography portfolio. For instance, in December 2021, Newton, New Jersey-based BioFlex Solutions was acquired by Repligen.

The acquisition expands and improves Repligen's portfolio of single-use fluid management products while also streamlining its supply chain. By adding BioFlex Solutions, the system offering is strengthened since more components and assemblies are integrated, driving segmental growth.

Based on the application, global downstream processing is divided into antibiotic production, hormone production, antibodies production, enzyme production, and vaccine production. The antibiotic production segment holds a significant market share over the forecast period. This rapid increase can be attributable to the broad range of conditions for which antibiotics are used as treatments. The annual death toll from antibiotic-resistant bacteria is above 700,000. Due to this, there is a strong need for the creation of antibiotics, which in turn drives market expansion.

The region that is dominating the downstream processing market is North America and will still retain its position in the coming years. The key factor that contributes to this dominance is it is the leading region for biopharmaceutical research and has a major market for pharmaceuticals worldwide. Asia Pacific is anticipated to be the fastest-growing market. The factors that attribute to this growth are the developing R&D infrastructure, substantial investments made by the market players, emerging academic excellence, and increasing government support are fueling the growth of the market in the Asia Pacific region.

This review is based on a report by Zion Market Research, titled Downstream Processing Market By Product (Chromatography Systems, Filters, Evaporators, Centrifuges, Dryers, and Others), By Technique (Cell Disruption, Solid-liquid Separation, Concentration, Purification by Chromatography and Formulation), By Application (Antibiotic Production, Hormone Production, Antibodies Production, Enzyme Production, and Vaccine Production), and By Region - Global and Regional Industry Overview, Market Intelligence, Comprehensive Analysis, Historical Data, and Forecasts 2022 – 2030.”- Report at

Recent Development:

  • In February 2022, the chromatography division of Novasep, which includes cutting-edge equipment for the continuous production of biologics as well as chromatography systems especially suitable for smaller biomolecules including oligonucleotides, peptides, and insulin, was acquired by Sartorius Stedim Biotech.

The global downstream processing market is dominated by players like:

  • Sartorius AG
  • GE Healthcare
  • Merck KGaA
  • Thermofisher Scientific
  • Danaher
  • Repligen Corporation
  • 3M
  • Boehringer Ingelheim International GmbH
  • Corning Incorporated
  • Lonza
  • Dover Corporation
  • Asahi Kasei Corporation
  • Eppendorf SE

The global downstream processing market is segmented as follows:

By Product

  • Chromatography Systems
  • Filters
  • Evaporators
  • Centrifuges
  • Dryers
  • Others

By Technique

  • Cell Disruption
  • Solid-liquid Separation
  • Concentration
  • Purification by Chromatography
  • Formulation

By Application

  • Antibiotic Production
  • Hormone Production
  • Antibodies Production
  • Enzyme Production
  • Vaccine Production

By Region

  • North America
    • The U.S.
    • Canada
  • Europe
    • France
    • The UK
    • Spain
    • Germany
    • Italy
    • Rest of Europe
  • Asia Pacific
    • China
    • Japan
    • India
    • South Korea
    • Southeast Asia
    • Rest of Asia Pacific
  • Latin America
    • Brazil
    • Mexico
    • Rest of Latin America
  • Middle East & Africa
    • GCC
    • South Africa
    • Rest of Middle East & Africa

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